Cefadroxil [Duricef 250mg, 500mg] Tablets
Drug Nomenclature
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Pharmacopoeias. In China, Europe, and US. Japan includes the anhydrous substance. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Cefadroxil Monohydrate). A white or almost white powder. Slightly soluble in water; very slightly soluble in alcohol. A 5% suspension in water has a pH of 4.0 to 6.0. Protect from light. The United States Pharmacopeia 31, 2008 (Cefadroxil). A white to off-white crystalline powder. Slightly soluble in water; practically insoluble in alcohol, in chloroform, and in ether. pH of a 5% suspension in water is between 4.0 and 6.0. Store in airtight containers.
Adverse Effects and Precautions
As for Cefalexin
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Breast feeding
Although higher concentrations of cefadroxil were reported in breast milk compared with cefalexin, cefalotin, cefapirin, and cefotaxime, no detectable cefadroxil would be expected in breast-fed infants and no adverse effects have been seen in infants whose mothers were receiving cefadroxil. Accordingly, the American Academy of Pediatrics considers that cefadroxil is usually compatible with breast feeding.
Cefadroxil: Interactions
As for Cefalexin.
Antimicrobial Action
As for Cefalexin.
Pharmacokinetics
Cefadroxil is almost completely absorbed from the gastrointestinal tract. After oral doses of 500 mg and 1 g, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment. Cefadroxil [Duricef 250mg, 500mg Tablets] is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk. More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.
Cefadroxil: Uses and Administration
Duricef 250mg, 500mg Tablets
Cefadroxil is a first-generation cephalosporin antibacterial that is the parahydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections. It is given orally, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil. The usual adult dose is 1 to 2 g daily as a single dose or in two divided doses. The following doses are used in children weighing less than 40 kg: 500 mg twice daily for those over 6 years of age, 250 mg twice daily for those aged 1 to 6 years, and 25 mg/kg daily in divided doses for infants under 1 year. For details of reduced doses of cefadroxil [Duricef 250mg, 500mg Tablets] in patients with renal impairment, see below. Cefadroxil [Duricef 250mg, 500mg Tablets] has also been used as the lysine derivative.
Administration in renal impairment
Following an initial loading dose of 0.5 to 1 g, dosage of cefadroxil should be adjusted in patients with renal impairment according to creatinine clearance (CC):
- CC 26 to 50 mL/minuteper 1.73 m: 0.5 to 1 g every 12 hours
- CC 11 to 25 mL/minuteper 1.73 m: 0.5 to 1 g every 24hours
- CC 10 mL/minute per 1.73 m or less: 0.5 to 1 g every 36 hours.
Preparations
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British Pharmacopoeia 2008: Cefadroxil Capsules; Cefadroxil Oral Suspension; The United States Pharmacopeia 31, 2008: Cefadroxil Capsules; Cefadroxil for Oral Suspension; Cefadroxil Tablet.
Proprietary Preparations
Argentina: Cefabiot; Cefacar; Cefacilina; Cefadrox; Cefamar; Cefasin; Cefatenk; Droxil; Kandicin; Klonadroxil; Versatic; Austria; Biodroxil; Duracef Belgium: Durace; Moxacef; Brazil: Cefadroxon; Cefamox; Celoxin; Drofaxil; Neo Cefadril; Canada: Durice; Chile: Adroxe; Biodroxil; Cefamox; Sedafex; Czech Republic: Biodroxil; Cedrox; Cefadrox; Durace; Finland: Durace; France: Oracefal; Germany; Cedrox; Grunce; Greece: Kleotrat; Moxace; Nefalox; Hong Kong; Amben; Androxyl; Biodroxil; Durace; Qualidrox; Sofidrox; Hungary: Biodroxil; Duracef India: Cefadrox; Cefadur; Lactocef Lydroxil; Odoxil; Pendrox; Vepan; Vistadrox; Indonesia: Alxil; Ancefa; Bidicef Biodroxil; Cefat; Dexacef Doxe; Durice; Erphadrox; Ethicef Kelfex; Lapice; Librocef Longce; Opice; Osadrox; Fyrice; Q Ce; Qidrox; Renasistin; Roksicap; Sedrofen; Staforin; Tisace; Widrox; Ireland: Ultrace; Israel: Biodroxil; Duracef; Italy: Cefadril; Ceoxil; Cephos; Foxil; Oradroxil; Malaysia: Kefloxin; Sofidrox; Mexico: Cefamox; Cepotec; Durace; Teroxina; Philippines: Drolex; Drozid; Lexipad; Poland: Biodroxil; Duracef Portugal: Biofaxil; Cefacile; Ceforal; Cefra; South Africa: Cipadur; Dace; Durace; Singapore: Durice; Sofidrox; Spain: Durace; Sweden: Cefamox; Turkey: Cefradur; Durice; UK: Baxan; USA: Duricef; Venezuela: Bidroxyl; Cedroxim; Cefaval; Cefonax; Droce; Droxifan; Grunice; Sanodril.
Multi-ingredient
Argentina: Cefacar Mucolitico; Cefacilina Bronquial; Mexico: Duracef Expec.
| Dosage forms of Cefadroxil: | |
|---|---|
| Cefadroxil 1 gm tablet | Duricef 1 gm tablet |
Synonyms of Cefadroxil:
CDX, Cefadroxil Monohydrate, Cefradroxil
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Therapeutic classes of Cefadroxil:
Anti-Bacterial Agents, Cephalosporins
Delivery
Australia, Canada, Mexico, New Zealand, USA, Europe [Belgium, France, Norway, Holland, Ireland, Spain, Switzerland, Great Britain (UK), Italy] and etc.