Ciclopirox
Drug Nomenclature
International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):
European Pharmacopoeia, 6th ed. (Ciclopirox).
A white or yellowish-white, crystalline powder. Slightly soluble in water freely soluble in alcohol and in diehloromethane. Protect from light.
The United States Pharmacopeia 31, 2008 (Ciclopirox).
A white to slightly yellowish white, crystalline powder. Slightly soluble in water freely soluble in dehydrated alcohol and in dichloromethane soluble in ether. Store at a temperature of 15° to 30°. Protect from light.
Ciclopirox Olamine
Drug Nomenclature
INNs in main languages (French, Latin, and Spanish):
Pharmacopoeias in China, Europe, and US
European Pharmacopoeia, 6th ed. (Ciclopirox Olamine)
A white or pale yellow crystalline powder. It exhibits polymorphism. Slightly soluble in water very soluble in alcohol and in dichloromethane slightly soluble in ethyl acetate practically insoluble in cyclohexane. A 1% solution in water has a pH of 8.0 to 9.0. Protect from light.
The United States Pharmacopeia 31, 2008 (Ciclopirox Olamine)
A white to slightly yellowish-white, crystalline powder. Slightly soluble in water very soluble in alcohol and in dichloromethane practically insoluble in cyclohexane. pH of a 1% solution in water is between 8.0 and 9.0. Store in airtight containers at a temperature of 5° to 25°. Protect from light.
Adverse Effects
Irritation and pruritus have been reported after topical application of ciclopirox.
Antimicrobial Action
Ciclopirox has a wide spectrum of antifungal activity. It inhibits most Candida, Epidermophyton, Microsporum, and Trichophyton spp. and is also active against Malassezia furfur. It has some antibacterial activity.
Uses and Administration
Ciclopirox is an antifungal that is applied topically in the treatment of fungal skin and nail infections, including cutaneous candidiasis, dermatophytosis, pityriasis versicolor (see Skin Infections), and seborrhoeic dermatitis. It has also been used in the treatment of vaginal candidiasis. It is applied twice daily for skin infections, as a cream, gel, suspension, solution, or powder both the base and the olamine salt have been used, with products containing the equivalent of 0.77% ciclopirox base. A lacquer containing 8% ciclopirox base is applied once daily for nail infections. A shampoo containing 1 % ciclopirox base is used twice weekly for the treatment of seborrhoeic dermatitis.
Preparations
The United States Pharmacopeia 31, 2008: Ciclopirox Olamine Cream Ciclopirox Olamine Topical Suspension.
Proprietary Preparations
| Country | Medication Names |
|---|---|
| Argentina | Dermaflor; Loprox; Micopirox; Stieprox; Derm’s Shampoo; Stieproxal |
| Australia | Stieprox |
| Austria | Batrafen; Stieprox |
| Brazil | Fungirox; Gino Loprox; Loprox; Micolamina; Micoliv; Stiprox |
| Canada | Loprox; Penlac; Stieprox |
| Chile | Batrafen; Fungopirox; Mikium; Stiprox |
| Czech Republic | Batrafen; Dafnegin; Stieprox |
| Denmark | Mycofen; Stieprox |
| Finland | Stieprox |
| France | Mycosquam; Mycoster; Sebiprox; Stiprox; Novophane; Novophane S; Stiproxal |
| Germany | Batrafen; Ciclopoli; Inimur; Myko Nagel Batrafen; Sebiprox |
| Greece | Candimyc; Dafnegin; Myclopir; Mycomycen; Neo-botacreme; Neo-mycodermol; Rozolam; Stieprox |
| Hong Kong | Batrafen; Stieprox |
| Hungary | Batrafen |
| India | Olamin; Onylac; Flucort-C |
| Indonesia | Batrafen; Loprox |
| Ireland | Batrafen; Oilatum Scalp Treatment; Stieprox |
| Israel | Batrafen; Cicloderm; Cicloderm-C |
| Italy | Batrafen; Biroxol; Brumixol; Dafnegin; Miclast; Micomicen; Micoxolamina; Sebiprox; Stiprox |
| Malaysia | Stieprox |
| Mexico | Loprox; Stiprox |
| The Netherlands | Loprox; Sebiprox |
| Norway | Stieprox |
| New Zealand | Batrafen; Stieprox |
| Philippines | Stieprox |
| Poland | Batrafen; Dafnegin; Hascofungin; Pirolam; Stieprox |
| Portugal | Batrafen; Mycoster; Sebiprox |
| Russia | Batrafen |
| Singapore | Stieprox |
| Spain | Batrafen; Ciclochem; Fungowas; Rimafungol; Sebiprox |
| Switzerland | Batrafen; Dafnegil Neo |
| Thailand | Cicloderm; Loprox; Stieprox |
| Turkey | Canolen; Nibu-len |
| UK | Oilatum Scalp Treatment; Oilatum Scalp Intensive |
| USA | Loprox; Penlac |
| Venezuela | Batrafen |