Atazanavir is a selective, competitive, reversible inhibitor of HIV-1 protease. It interferes with the formation of essential viral proteins making them incapable of infecting other cells. Viral resistance develops rapidly when HIV-protease inhibitors are given alone and therefore they are used with other antiretrovirals.
Author: Donna Brettler
Natamycin
Natamycin is a polyene antifungal active against Candida and Fusarium spp. In addition it is active against the protozoan Trichomonas vaginalis.
Miconazole
Miconazole is an imidazole antifungal with similar antimicrobial activity to that of ketoconazole. It also has some activity against Aspergillus spp., Cryptococcus neoformans, Pseudallescheria boydii, and some Gram-positive bacteria including staphylococci and streptococci.
Nizoral (Ketoconazole)
Ketoconazole has a wide spectrum of antimicrobial activity including activity against Blastomyces dermatitidis, Candida spp., Coccidioides immitis, Epidermophyton floccosum, Histoplasma capsulatum, Malassezia spp., Microsporum canis, Paracoccidioides brasiliensis, Trichophyton mentagrophytes, and T. rubrum. Some strains of’Aspergillus spp., Cryptococcus neoformans, and Sporothrix schenckii are sensitive.
Sporanox (Itraconazole)
Itraconazole can be used to treat various superficial fungal infections, including dermatophytoses, pityriasis versicolor, and mucosal and cutaneous forms of candidosis.
Grifulvin (Griseofulvin)
Griseofulvin is a fungistatic antibiotic that inhibits fungal cell division by disruption of the mitotic spindle structure. It may also interfere with DNA production. It is active against the common dermatophytes, including some species of’ Epidermophyton, Microsporum, or Trichophyton.
Flucytosine
Flucytosine is active against Candida spp., Cryptococcus neoformans, Cladosporium spp., and Fonsecaea spp. Some Aspergillus spp. have also been reported to be sensitive.
Econazole
Econazole is an imidazole antifungal used topically in the treatment of superficial candidiasis and in dermatophytosis and pityriasis versicolor.
Clotrimazole
Clotrimazole is an imidazole antifungal used topically in superficial candidiasis, and in the skin infections pityriasis versicolor and dermatophytosis (see Skin Infections). Clotrimazole may also be used occasionally for symptomatic relie of the protozoal infection trichomoniasis when other drugs are contra-indicated.
Ciclopirox
Ciclopirox is an antifungal that is applied topically in the treatment of fungal skin and nail infections, including cutaneous candidiasis, dermatophytosis, pityriasis versicolor (see Skin Infections), and seborrhoeic dermatitis.