Zyvox (Linezolid) 100mg/5ml Granules for Oral Suspension
What Zyvox is and what it is used for
Zyvox is an antibiotic of the oxazolidinones group that works by stopping the growth of certain bacteria (germs) that cause infections. It is used to treat pneumonia and some infections in the skin or under the skin. Your doctor will have decided if Zyvox is suitable to treat your infection.
Before you take Zyvox
Read indications for use if you want to order Linezolid online
Do not take Zyvox if you are:
- allergic (hypersensitive) to linezolid or any of the other ingredients of this medicine
- taking or have taken within the last 2 weeks any medicines known as monoamine oxidase inhibitors (MAOIs for example phenelzine, isocarboxazid, selegiline, moclobemide). These may be used to treat depression or Parkinson’s disease
- you are breastfeeding. This is because it passes into breast milk and could affect the baby.
Zyvox may not be suitable for you if you answer yes to any of the following questions. In this case tell your doctor as he/she will need to check your general health and your blood pressure before and during your treatment or may decide that another treatment is better for you. Ask your doctor if you are not sure whether these categories apply to you.
- Do you have high blood pressure?
- Have you been diagnosed with an overactive thyroid?
- Do you have a tumour of the adrenal glands (phaeochromocytoma) or carcinoid syndrome (caused by tumours of the hormone system with symptoms of diarrhoea, flushing of the skin, wheezing )?
- Do you suffer from manic depression, schizoaffective disorder, mental confusion or other mental problems?
- Are you taking any of the following medicines?
- decongestant cold or flu remedies containing pseudoephedrine or phenylpropanolamine
- medicines used to treat asthma such as salbutamol, terbutaline, fenoterol
- antidepressants known as tricyclics or SSRIs (selective serotonin reuptake inhibitors). For example amitriptyline, cipramil, clomipramine, dosulepin, doxepin, fluoxetine, fluvoxamine, imipramine, lofepramine, paroxetine; sertraline
- medicines used to treat migraine such as sumatriptan and zolmitriptan
- medicines used to treat sudden, severe allergic reactions such as adrenaline (epinephrine) -medicines which increase your blood pressure, such as noradrenaline (norepinephrine),dopamine and dobutamine
- medicines used to treat moderate to severe pain, such as pethidine
- medicines used to treat anxiety disorders, such as buspirone.
- an antibiotic called rifampicin
Before buy Linezolid online, read information about the drug
Take special care with Zyvox
Tell your doctor before you take this medicine if you:
- bruise and bleed easily
- are anaemic
- are prone to getting infections
- have a history of seizures
- have liver problems or kidney problems particularly if you have dialysis
- have diarrhoea
Tell your doctor immediately if during treatment you suffer from:
- problems with your vision such as blurred vision, changes in colour vision, difficulty in seeing detail or if your field of vision becomes restricted.
- you may develop diarrhoea while taking or after taking antibiotics, including Zyvox. If this becomes severe or persistent or you notice that your stool contains blood or mucus, you should stop taking Zyvox immediately and consult your doctor. In this situation, you should not take medicines that stop or slow bowel movement.
- recurrent nausea or vomiting, abdominal pain or over breathing.
Taking other medicines
There is a risk that Zyvox may sometimes interact with certain other medicines to cause side effects such as changes in blood pressure, temperature or heart rate
Tell your doctor if you are taking or have taken within the last 2 weeks the following medicines as Zyvox must not be taken if you are already taking these medicines or have taken them recently.
- monoamine oxidase inhibitors (MAOIs, for example phenelzine, isocarboxazid, selegiline, moclobemide). These may be used to treat depression or Parkinson’s disease
Also tell your doctor if you are taking the following medicines. Your doctor may still decide to give you Zyvox, but will need to check your general health and your blood pressure before and during your treatment. In other cases, your doctor may decide that another treatment is better for you.
- Decongestant cold or flu remedies containing pseudoephedrine or phenylpropanolamine.
- Some medicines used to treat asthma such as salbutamol, terbutaline, fenoterol.
- Certain antidepressants known as tricyclics or SSRIs (selective serotonin reuptake inhibitors). There are many of these, including amitriptyline, cipramil, clomipramine, dosulepin, doxepin, fluoxetine, fluvoxamine, imipramine, lofepramine, paroxetine, sertraline.
- Medicines used to treat migraine such as sumatriptan and zolmitriptan.
- Medicines used to treat sudden, severe allergic reactions such as adrenaline (epinephrine).
- Medicines which increase your blood pressure, such as noradrenaline (norepinephrine), dopamine and dobutamine.
- Medicines used to treat moderate to severe pain, such as pethidine.
- Medicines used to treat anxiety disorders, such as buspirone.
- Medicines that stop blood clotting, such as warfarin.
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Taking Zyvox with food and drink
- You can take Zyvox either before, during or after a meal.
- Avoid eating large amounts of mature cheese, yeast extracts, or soya bean extracts e.g. soy sauce and drinking alcohol, especially draught beers and wine. This is because this medicine may react with a substance called tyramine which is naturally present in some foods to cause an increase in your blood pressure.
- If you develop a throbbing headache after eating or drinking, tell your doctor or pharmacist immediately.
Pregnancy and breast-feeding
The effect of Zyvox in pregnant women is not known. Therefore it should not be taken in pregnancy unless advised by your doctor. Tell your doctor if you are pregnant, think you may be pregnant or are trying to become pregnant. You should not breastfeed when taking Zyvox because it passes into breast milk and could affect the baby.
Driving and using machines
Zyvox may make you feel dizzy or experience problems with your vision. If this happens, do not drive or operate any machinery. Remember that if you are unwell your ability to drive or operate machinery may be affected.
Important information about some of the ingredients in Zyvox
Aspartame
Aspartame, a sweetening agent, is partly converted into phenylalanine in the body. This may be harmful for people with phenylketonuria.
Sucrose and fructose
Sucrose and fructose are sugars. If you have been told that you have an intolerance to some sugars contact your doctor before talking this medicine. Sucrose and fructose may also be harmful to the teeth.
Sodium
When made up into a suspension this medicine contains 51 mg of sodium per dose (8.5mg per 5ml). This should be taken into consideration if you are on a controlled sodium diet.
How to take Zyvox
When you buy cheap Levofloxacin you must know how to use it
Always take Zyvox as your doctor has told you. If you are unsure ask your doctor or pharmacist. Zyvox comes as granules which will be made up by the pharmacist to make a suspension for you to take.
Adults
The usual dose of Zyvox suspension is six 5ml spoonfuls (600mg linezolid) twice daily (every 12 hours). Before using, gently turn the the bottle upside down a few times. DO NOT SHAKE. If you are on kidney dialysis, you should take Zyvox after your dialysis treatment
A course of treatment usually lasts 10 to 14 days but can last up to 28 days. The safety and effectiveness of this medicine have not been established for treatment periods longer than 28 days. Your doctor will decide how long you should be treated.
While you are taking Zyvox, your doctor should perform regular blood tests to monitor your blood count.
Your doctor should monitor your eyesight if you take Zyvox for more than 28 days.
Children
Zyvox is not normally used to treat children and adolescents (under 18 years old).
If you take more Zyvox than you should
Tell your doctor or pharmacist immediately.
If you forget to take Zyvox
Take the forgotten dose of medicine as soon as you remember. Take the next dose 12 hours after this and continue taking the medicine every 12 hours. Do not take twice as much medicine to make up for missing a dose.
If you stop taking Zyvox
Unless your doctor instructs you to stop treatment, it is important to continue taking Zyvox. If you stop and your original symptoms come back tell your doctor or pharmacist immediately.
Possible side effects
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Like all medicines Zyvox can cause side-effects although not everybody gets them.
Tell you doctor, nurse or pharmacist immediately if you notice any of these side effects during your treatment with Zyvox:
- skin reactions such as red sore skin and flaking (dermatitis), rash, itching, or swelling, particularly around the face and neck. This may be the sign of an allergic reaction and it may be necessary for you to stop taking Zyvox.
- problems with your vision such as blurred vision, changes in colour vision, difficulty in seeing detail or if your field of vision becomes restricted.
- severe diarrhoea containing blood and/or mucus (antibiotic associated colitis including pseudomembranous colitis), which in very rare circumstances may develop into complications that are life-threatening.
- recurrent nausea or vomiting, abdominal pain or over breathing.
- fits or seizures have been reported with Zyvox. You should let your doctor know if you experience agitation, confusion, delirium, rigidity, tremor, incoordination and seizure while also taking antidepressants known as SSRI’s (see section 2).
Numbness, tingling or blurred vision have been reported by patients who have been given Zyvox for more than 28 days. If you experience difficulties with your vision you should consult your doctor as soon as possible.
Other side effects include:
Common side-effects (likely to occur in less than 1 in 10 people):
- Fungal infections especially vaginal or oral “thrush”
- Headache
- Metallic taste in the mouth
- Diarrhoea, nausea or vomiting
- Changes in some blood test results including those measuring your kidney or liver function or blood sugar levels
- Unexplained bleeding or bruising, which may be due to changes in the numbers of certain cells in the blood which may affect blood clotting or lead to anaemia
Uncommon side-effects (likely to occur in less than 1 in 100 people):
- Inflammation of the vagina or genital area in women
- Changes in numbers of certain cells in the blood which may affect your ability to fight infection
- Difficulty in sleeping
- Dizziness, sensations such as tingling or feeling numb
- Blurred vision
- “Ringing” in the ears (tinnitus)
- Increased blood pressure, inflammation of the veins
- Indigestion, stomach pain, constipation
- Dry or sore mouth , swollen, sore, or discoloured tongue
- Skin rash
- A need to urinate more often
- Fever or chills, aches and pains
- Feeling tired or thirsty
- Inflammation of the pancreas
- Increased sweating
- Changes in proteins, salts or enzymes in the blood which measure kidney or liver function.
- Reduction in the numbers of cells in the blood which fight against infection.
Rare side-effects (likely to occur in less than 1 in 1000 people):
- Changes in heart rate (eg, increase rate)
- Transient ischaemic attacks (temporary disturbance of blood flow to the brain causing short term symptoms such as loss of vision, leg and arm weakness, slurring of speech and loss of consciousness),
- Kidney failure
The following side effects have also been reported (frequency not known):
- Serotonin syndrome (symptoms include fast heart rate, confusion, abnormal sweating, hallucinations, involuntary movements chills and shivering)
- Lactic acidosis (symptoms include recurrent nausea and vomiting, abdominal pain, overbreathing)
- Severe skin disorders
- Convulsions
- Superficial tooth discolouration, removable with professional dental cleaning (manual descaling)
- Alopecia (hair loss)
- Hyponatraemia (low blood sodium levels)
- Changes in colour vision, difficulty in seeing detail or if your field of vision becomes restricted
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
How to store Zyvox
Before purchase Levofloxacin, you must read how to store
Keep out of the reach and sight of children.
Keep the bottle in the outer carton in order to protect from light.
Do not use the suspension after the expiry date which is stated on the label. The expiry date refers to the last day of the month.
Any remaining suspension should be discarded within 21 days of reconstitution.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help us to protect the environment.
Further information
What Zyvox granules for oral suspension contain
- The active substance is linezolid. Each bottle contains 66 g of granules providing 150 ml of suspension when reconstituted with 123 ml water by the pharmacist or health care professional. Each 5ml of suspension contains lOOmg linezolid.
- Other ingredients are sucrose, mannitol, microcrystalline cellulose (E460), carboxymethylcellulose sodium (E466) aspartame, anhydrous colloidal silica (E551), sodium citrate, xanthan gum, sodium benzoate, citric acid anhydrous, sodium chloride, sweeteners (fructose, maltodextrin, monoammonium glycyrrhizinate, sorbitol). Flavourings are orange, orange cream, peppermint and vanilla.
What Zyvox looks like and contents of the pack
Zyvox granules for oral suspension are supplied in a brown bottle containing white to light yellow orange flavoured granules providing an orange-flavoured liquid (suspension) when made up with water Each bottle is packaged in a carton with a 2.5ml/5ml measuring spoon.
Marketing Authorisation Holder and Manufacturer
The Marketing Authorisation Holder is Pharmacia Limited, Sandwich, Kent, CT13 9NJ, UK and the manufacturer is Pfizer Manufacturing Belgium NV, Rijksweg 12, B-2870 Puurs, Belgium.
Company contact address: Medical Information Department, Pfizer Limited, Walton Oaks, Dorking Road, Tadworth, Surrey KT20 7NS. Telephone: 01304 616 161.
This medicinal product is authorised in the Member States of the EEA under the following names:
| Austria | Zyvoxid |
| Belgium | Zyvoxid |
| Cyprus | Zyvoxid |
| Czech Republic | Zyvoxid |
| Denmark | Zyvoxid |
| Estonia | Zyvoxid |
| Finland | Zyvoxid |
| France | Zyvoxid |
| Germany | Zyvoxid |
| Greece | Zyvoxid |
| Hungary | Zyvox |
| Iceland | Zyvoxid |
| Ireland | Zyvox |
| Italy | Zyvoxid |
| Latvia | Zyvoxid |
| Lithuania | Zyvoxid |
| Luxembourg | Zyvoxid |
| Malta | Zyvox |
| Netherlands | Zyvoxid |
| Norway | Zyvoxid |
| Poland | Zyvoxid |
| Portugal | Zyvoxid |
| Slovakia | Zyvoxid |
| Slovenia | Zyvoxid |
| Spain | Zyvoxid |
| Sweden | Zyvoxid |
| Dosage forms of Linezolid: | |
|---|---|
| Zyvox 600 mg tablet | Zyvox 200 mg/100 ml iv soln |
Synonyms of Linezolid:
Linezolid
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Therapeutic classes of Linezolid:
Anti-Infective Agents, Antibacterial Agents, Protein Synthesis Inhibitors
Delivery
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