While fluconazole can alter the pharmacokinetics of certain drugs that undergo hepatic metabolism, the magnitude of such alterations appears to be less than those associated with ketoconazole; however, comparative studies have not been performed to date. In addition, the possibility that the risk of developing such interactions may be increased at relatively high fluconazole dosages (e.g., 200 mg daily or more) should be considered. Results of studies evaluating combined use of fluconazole and amphotericin B in animal models of aspergillosis, candidiasis, or cryptococcosis have been conflicting.
Uses, Dosages and Administration of Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)
Fluconazole is administered orally or by IV infusion. Since absorption of fluconazole from the GI tract is rapid and almost complete, IV therapy with the drug generally is reserved for patients who do not tolerate or are unable to take the drug orally.
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Terbinafine hydrochloride is a synthetic allylamine antifungal agent. Terbinafine is structurally and pharmacologically related to naftifine.
Quinupristin and Dalfopristin
Quinupristin and dalfopristin is a combination of 2 semisynthetic streptogramin (synergistin) antibiotics that act synergistically against susceptible gram-positive bacteria.
Quinupristin and Dalfopristin: Dosage and Administration
Quinupristin and dalfopristin is administered by IV infusion over 60 minutes. Quinupristin and dalfopristin powder for injection must be reconstituted and diluted prior to administration. The manufacturer states that only 5% dextrose injection or sterile water for injection should be used to reconstitute the powder, and further dilution should be with 5% dextrose. Strict aseptic technique must be observed since the drug contains no preservative.
Polymyxin B Sulfate
Systemic use of polymyxin B has, in most cases, been replaced by more effective and less toxic antibiotics for infections caused by susceptible organisms. However, polymyxin B may be useful in infections caused by organisms resistant to these drugs.
Colistimethate Sodium
Colistimethate sodium is used in the treatment of acute or chronic infections caused by susceptible strains of certain gram-negative bacteria (e.g., Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa).
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Linezolid is used orally and/or IV for the treatment of vancomycin-resistant Enterococcus faecium infections and for the treatment of community-acquired pneumonia, nosocomial pneumonia, and uncomplicated or complicated skin and skin structure infections caused by susceptible staphylococci or streptococci.
Lincomycin Hydrochloride
Lincomycin should be not used for the treatment of minor bacterial infections or for nonbacterial infections. Because of poor CNS penetration, lincomycin should not be used in the treatment of meningitis.
Lincomycin Hydrochloride: Cautions
Adverse GI effects frequently occur with oral, IM, or IV lincomycin and may be severe enough to necessitate discontinuance of the drug. Adverse GI effects of lincomycin include nausea, vomiting, diarrhea, abdominal pain, tenesmus, glossitis, stomatitis, and pruritus ani.