Lincomycin is a lincosamide antibacterial with actions and uses similar to those of its chlorinated derivative, clindamycin.
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Cefalexin is a first-generation cephalosporin antibacterial. It is given orally for the treatment of susceptible infections including those of the respiratory and urinary tracts and of the skin.
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Cefadroxil is a first-generation cephalosporin antibacterial that is the parahydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections.
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Roxithromycin is a macrolide antibacterial with actions and uses similar to those of erythromycin. It is given orally to adults in a usual dose of 150 mg twice daily or sometimes 300 mg once daily, at least 15 minutes before meals, for 5 to 10 days in the treatment of susceptible infections.
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Minocycline has a spectrum of activity and mode of action similar to that of tetracycline but it is more active against many species including Staphylococcus aureus, streptococci, Neisseria meningitidis, various enterobacteria, Acinetobacter, Bacteroides, Haemophilus, Nocardia, and some mycobacteria, including M. leprae.
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Linezolid is an oxazolidinone antibacterial with activity against a range of aerobic Gram-positive bacteria including vancomycin-resistant enterococci and meticillin-resistant Staphylococcus aureus. It is less active against Gram-negative bacteria, but has some in-vitro activity against Haemophilus influenzae, Legionella spp., Moraxella catarrhalis (Branhamella catarrhalis), Neisseria gonorrhoeae, and Pasteurella spp.
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Levofloxacin is generally considered to be about twice as active as ofloxacin, the racemic substance. Levofloxacin has a broad spectrum of activity which includes Gram-positive bacteria.
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Gatifloxacin is reported to have greater activity against Gram-positive bacteria, including pneumococci, than ciprofloxacin.
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Fusidic acid is a steroidal antibacterial with a bacteriostatic or bactericidal activity, mainly against Gram-positive bacteria. Fusidic acid inhibits bacterial protein synthesis although, in contrast to drugs such as the macrolides or tetracyclines, it does not bind to the bacterial ribosome, but inhibits a factor necessary for translocation of peptide subunits and elongation of the peptide chain.
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Fosfomycin is a bactericidal antibacterial. After active uptake into the cell it is reported to interfere with the first step in the synthesis of bacterial cell walls. It is active in vitro against a range of Gram-positive and Gram-negative bacteria including Staphylococcus aureus, some streptococci, most Enterobacteriaceae, Haemophilus influenzae, Neisseria spp., and some strains of’ Pseudomonas aeruginosa although some are resistant. Bacteroides spp. are not sensitive.